Principal Investigator Collin Stultz
Project Start Date July 2020
We have developing novel methods to model the unfolded states of intrinsically disordered systems. This exercise is of paramount importance as many disordered proteins have been implicated in a number of neurodegenerative disorders, such as Alzheimer’s disease.. We have applied our methods to understand the unfolded state of the intrinsically disordered proteins, tau protein, alpha synuclein, and abeta. Our goal is to understand how these proteins contribute to the pathogenesis of disease using a combination of physically based calculations and biochemical data.